To the left are links to the protocols for the various binding assays used by the PDSP. For each receptor type the radioligand, assay buffer, incubation time and temperature and, unlabeled ligand are listed. Also, included with the protocol are representative results.
Receptors for PDSP Assay Protocol Book General binding conditions pdf version. (Download Adobe Acrobat Reader)     Protocols References   Ki determinations, agonist/antagonist functional data, HERG data and/or MDR1 data was generously provided by the National Institute of Mental Health's Psychoactive Drug Screening Program (NIMH PDSP). The NIMH PDSP is Directed by Bryan L. Roth MD, PhD at the University of North Carolina at Chapel Hill and Project Officer Jamie Driscol at NIMH, Bethesda MD, USA. Contract # NO1MH32004. If significant analysis and/or consulting was provided by the NIMH PDSP staff please include the appropriate person(s) as an author.
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