Roth Lab in the news

Recent:

Huang et al, "Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature 2011 Dec 21. doi: 10.1038/nature10726. [Epub ahead of print]

• Science: "New Hope for a Devastating Neurological Disorder"
• Nature: "Angelman syndrome: Drugs to awaken a paternal gene"
• Nature News: "A wake-up call for dormant genes"
• NIMH Top 10 Research Advances of 2011
• The Scientist: "Unsilencing a gene"

Allen et al, Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. PNAS U S A. 2011 Nov 8;108(45):18488-93

• SciBx: Arrestin Psychosis
• Schizophrenia Research Forum

Drug Discovery:

Nature: "New targets for old drugs"
Nature: "Drug discovery: predicting promiscuity"
Nature: "Drug discovery: playing dirty" "Drug discovery: playing dirty"

• "All Things Considered"
  • Salvia ingredient studied as medical treatment
  • Why scientists think salvia could lead to medical treatments
  • Salvia: legal herb hallucinogen draws teens, critics
• "Popularity of a hallucinogen may thwart its medical uses"
• Video
•  CBS News Early Show

• "Studies find harm in 2 Parkinson's Drugs"
• National Public Radio 'All Things Considered': "Parkinson's linked to heart problems"
• And many others (LA Times, Wall Street Journal, Reuters, AP, UPI)