Roth Lab in the news

Recent:

Wacker et al, Structural Features for Functional Selectivity at Serotonin Receptors. Science. 2013 Mar 21. [Epub ahead of print]
Wang et al, Structural Basis for Molecular Recognition at Serotonin Receptors. Science. 2013 Mar 21. [Epub ahead of print]

• Nature News & Comment (21 March 2013) Serotonin receptors offer clues to new antidepressants
• Web Date: March 22, 2013
  Avoiding The Death Receptor
• Science World Report,Web Date: March 27, 2013
  Experimenting With LSD, Scientists Decipher Two Serotonin Receptors
• Brain & Behavior Research Foundation
  New Technology Enables New Insights Pointing toward Safer Schizophrenia Medications
• Schizophrenia Research Forum Web date: March 26, 2013
  The Structure of Bias at Serotonin Receptors
• e! Science News Web date: March 241, 2013
  Study reveals how serotonin receptors can shape drug effects from LSD to migraine medication

Besnard et al, Automated design of ligands to polypharmacological profiles. Nature. 2012 Dec 13;492(7428):215-20. doi: 10.1038/nature11691

• Nature Reviews Drug Discovery 12, 101 (February 2013) Computational chemistry: Homing in on desired drug properties
• Brain & Behavior Research Foundation NARSAD Grantee Leads Work in Designing More Effective Medications
• Web Date: December 24, 2012
  Drug Design On The Fast Track
• Science Daily Science News
  Study Paves Way to Design Drugs Aimed at Multiple Protein Targets at Once

Garner et al, Generation of a Synthetic Memory Trace. Science. 2012 Mar 23;335(6075):1513-6 doi: 10.1126/science.1214985

• Science: Issue Highlights > Memory Traces Contain More Than Memory

Wu et al, Structure of the human kappa-opioid receptor in complex with JDTic. Nature. 2012 Mar 21. doi: 10.1038/nature10939.

• Nature: Opioid receptors revealed
• Solving Addiction
• Opioid Receptors Revealed

Huang et al, Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726.

• Science: "New Hope for a Devastating Neurological Disorder"
• Nature: "Angelman syndrome: Drugs to awaken a paternal gene"
• Nature News: "A wake-up call for dormant genes"
• NIMH Top 10 Research Advances of 2011
• The Scientist: "Unsilencing a gene"

Allen et al, Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. PNAS U S A. 2011 Nov 8;108(45):18488-93

• SciBx: Arrestin Psychosis
• Schizophrenia Research Forum

Drug Discovery:

Nature: "New targets for old drugs"
Nature: "Drug discovery: predicting promiscuity"
Nature: "Drug discovery: playing dirty" "Drug discovery: playing dirty"

• "All Things Considered"
  • Salvia ingredient studied as medical treatment
  • Why scientists think salvia could lead to medical treatments
  • Salvia: legal herb hallucinogen draws teens, critics
• "Popularity of a hallucinogen may thwart its medical uses"
• Video
•  CBS News Early Show

• "Studies find harm in 2 Parkinson's Drugs"
• National Public Radio 'All Things Considered': "Parkinson's linked to heart problems"
• And many others (LA Times, Wall Street Journal, Reuters, AP, UPI)