PDSP Home Ki Database PDSP Database SNIDD/Tracer Database
Name: Bryan Roth
Email: bryan_roth@med.unc.edu
Hometown:
Title: Big Kahuna
rothlab

Publications:

Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL. Predicting new molecular targets for known drugs.  Nature. 2009 Nov 12;462(7270):175-81

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs.  Nat Methods. 2008 Aug;5(8):673-8

Ferguson SM, Eskenazi D, Ishikawa M, Wanat MJ, Phillips PE, Dong Y, Roth BL, Neumaier JF. Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization.  Nat Neurosci. 2011 Jan;14(1):22-4. Epub 2010 Dec 5.

Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling.  Nat Neurosci. 2010 May;13(5):622-9

Dong S, Rogan SC, Roth BL. Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs.  Nat Protoc. 2010;5(3):561-73

Alexander GM, Rogan SC, Abbas AI, Armbruster BN, Pei Y, Allen JA, Nonneman RJ, Hartmann J, Moy SS, Nicolelis MA, McNamara JO, Roth BL. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.  Neuron. 2009 Jul 16;63(1):27-39.

Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G. Endocrine Regulation of Male Fertility by the Skeleton.  Cell. 2011 Mar 4;144(5):796-809. Epub 2011 Feb 17

O'Connor KA, Roth BL. Finding new tricks for old drugs: an efficient route for public-sector drug discovery.  Nature Rev Drug Discov. Dec;4(12):1005-14, 2005

Roth BL, Sheffler DJ, Kroeze WK. Opinion: Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.  Nat Rev Drug Discov. 2004 Apr;3(4):353-9

Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand..  Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8. Epub 2007 Mar 2

Guettier JM, Gautam D, Scarselli M, Ruiz de Azua I, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J. A chemical-genetic approach to study G protein regulation of beta cell function in vivo.  Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19197-202

Jones KA, Srivastava DP, Allen JA, Strachan RT, Roth BL, Penzes P. Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling.  Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19575-80. Epub 2009 Nov 4

Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.  Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11934-9. Epub 2002 Aug 21

Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Bruning JC, Roth BL. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling..  Proc Natl Acad Sci U S A 2006 Mar 21;103(12):4717-22. Epub 2006 Mar 10

Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ. The human polyomavirus, JCV, uses serotonin receptors to infect cells.  Science. 2004 Nov 19;306(5700):1380-3

Berger M, Gray JA, Roth BL. The expanded biology of serotonin.  Annu Rev Med. 2009;60:355-66. Review.

Roth BL. Drugs and valvular heart disease.  N Engl J Med. 2007 Jan 4;356(1):6-9

Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL. PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.  J Neurosci. 2009 Jun 3;29(22):7124-36

Abbas AI, Urban DJ, Jensen NH, Farrell MS, Kroeze WK, Mieczkowski P, Wang Z, Roth BL. Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method.  Nucleic Acids Res. 2010 Jun;38(10):e118

Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J. Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1.  Neuron, Vol 45, Issue 4, 3 February 2005