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| Name: | Vincent Setola |
| Email: | vsetola@gmail.com |
| Hometown: | Washington, DC |
| Title: | Research Assistant Professor and Associate Assistant Director |
| Education: |
| BS , University of Maryland - College Park 1997 | | MSc , Université Pierre et Marie Curie, Paris, France 1999 | | Ph.D. , Case Western Reserve University 2004 |
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No picture on file
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Research:
Interactions of drugs with serotonin 5-HT2B receptors and the implications for cardiopulmonary toxicity; serotonin receptor ligand structure-activity studies
Future research:
GPCR structure-function; GPCR regulation; GPCR signal transduction
Publications:
Setola V, Dukat M, Glennon RA, Roth BL. Molecular Determinants for the Interaction of the Valvulopathic Anorexigen Norfenfluramine with the 5-HT2B Receptor. Mol Pharmacol. 2005 Jul;68(1):20-33. Epub 2005 Apr 14
Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Blough B, Rothman RB, Roth BL. 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Mol Pharmacol. 2003 Jun;63(6):1223-9
Setola, V and Roth, BL. Elucidating the atomic determinants for the interaction of the valvulopathic drug norfenfluramine with its molecular target: the serotonin 5-HT2B receptor (in preparation).
Chang-Fong J, Rangisetty JB, Dukat M, Setola V, Raffay T, Roth B, Glennon RA. 1,2,3,4-tetrahydrocarbazoles as 5-HT6 serotonin receptor ligands.. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1961-4
Pullagurla MR, Dukat M, Setola V, Roth B, Glennon RA. N1-benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT6 receptor ligand templates.. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3355-9
Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Discovery of a novel member of the histamine receptor family. Mol Pharmacol. 2001 Mar;59(3):427-33
Setola V, Roth BL. Why mice are neither miniature humans nor small rats: a cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants. Mol Pharmacol. 2003 Dec;64(6):1277-8
Other interests:
Music, Cooking, Oenophilia
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