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| Name: | Doug Sheffler |
| Email: | douglas.sheffler@vanderbilt.edu |
| Hometown: | Ligonier, Pennsylvania |
| Title: | Fellow,Department of Pharmacology, Vanderbilt University |
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Research:
In Bryan Roth's lab, my graduate work has focused on the regulation of signaling of the 5-hydroxytryptamine 2A (5-HT2A) receptor. Specifically, I have characterized a novel interaction between the third intracellular (i3) loop of the 5-HT2A receptor and a member of the mitogen-activated protein kinase family, RSK2. This interaction has been found to have profound effects on 5-HT2A receptor signaling.
Future research:
My interests are in the complex regulation of G-protein coupled receptors (GPCRs): GPCR signal transduction, ligand binding, receptor desensitization, and the processes of GPCR internalization and down-regulation. I have a specific interest in the pharmacology of GPCRs, but I am also interested in the
mechanisms of signal transduction in general.
Publications:
Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL. Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to kappa-Opioid Receptors. Biochemistry. 2005 Jun 21;44(24):8643-8651
Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth BA, Roth BL. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Gaq-coupled GPCRs . J. Biol. Chem. published 9 June 2004, 10.1074/jbc.M404673200
Roth BL, Sheffler DJ, Kroeze WK. Opinion: Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov. 2004 Apr;3(4):353-9
Sheffler DJ, Roth BL. Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor. Trends Pharmacol Sci 2003 Mar;24(3):107-9
Kroeze WK, Sheffler DJ, Roth BL. G-protein-coupled receptors at a glance. J Cell Sci 2003 Dec 15;116(Pt 24):4867-9
Other interests:
I recently was married to Allison Limpert, another fifth year graduate student in the Neurosciences department, and had a lovely honeymoon on the islands of Maui and Hawaii in Hawaii. When I'm not in the lab, I'm spending time with my lovely wife and our cat Scout.
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