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| Name: | John Gray |
| Email: | jgray@lppi.ucsf.edu |
| Hometown: | Newark, Ohio |
| Title: | MD, PhD: Fellow UCSF Department of Pharmacology (Roger Nicoll lab) |
| Education: |
| B.S. in Biochemistry, Case Western Reserve University 1997 | | Ph.D. in Biochemistry, Case Western Reserve University 2003 | | M.D. , Case Western Reserve University 2005 |
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Publications:
Gray JA, Compton-Toth BA, Roth BL. Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization. Biochemistry 2003 Sep 16;42(36):10853-62
Xia Z, Gray JA, Compton-Toth BA, Roth BL. A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem 2003 Jun 13;278(24):21901-8. Epub 2003 Apr 07
JA Gray and BL Roth. A last GASP for GPCR's?. Science 297: 529-531,2002
John A. Gray1 and Bryan L. Roth. Developing selectively nonselective drugs for treating CNS disorders. Drug Discovery Today, in press.
Gray JA and Roth BL. Serotonin (5-HT) Systems. In Sibley D, Hanin I and Kuhar M (Eds.) Handbook of Contemporary Neuropharmacology. John Wiley & Sons, New York, NY, in press
Xia Z, Hufeisen SJ, Gray JA, and Roth BL. The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro.. Neuroscience. 2003;122(4):907-20.
Gray JA , Bhatnagar A, Gurevich VV, and Roth BL. The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT2A receptor induces agonist-independent internalization.. Mol Pharmacol. 2003 May;63(5):961-72.
Gray JA and Roth BL. Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists. Brain Res Bull. 2001 Nov 15;56(5):441-51.
Gray JA , Sheffler DJ, Bhatnagar A, Woods JA, Hufeisen SJ, Benovic JL, and Roth BL. Cell-type specific effects of endocytosis inhibitors on 5-HT2A receptor desensitization and resensitization reveal an arrestin-, GRK2- and GRK5-independent mode of regulation in HEK-293 cells.. Mol Pharmacol. 2001 Nov;60(5):1020-30.
Bhatnagar A, Willins DL, Gray JA, Woods JA, Benovic JL, and Roth BL The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis.. J Biol Chem. 2001 Mar 16;276(11):8269-77. Epub 2000 Nov 7.
Gelber EI, Kroeze WK, Willins DL, Gray JA, Sinar CA , Hyde EG, Gurevich V, Benovic JL, Roth BL. Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins.. Journal of Neurochemistry 1999; 72: 2206-2214
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