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| Name: | Katherine Caldwell |
| Email: | katherine.alex@case.edu |
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| Title: | PhD visiting assistant Professor Oberlin University Neurosciences Department |
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Research:
Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA.
Modulation of dopamine release by striatal 5-HT2C receptors.
Synapse. 2005 Mar 15;55(4):242-51.
Previous work has demonstrated that dopamine (DA) transmission is regulated by serotonin-2C (5-HT2C) receptors but the site(s) in the brain where these receptors are localized is not known. The present work utilized in vivo microdialysis to investigate the modulation of DA release by 5-HT2C receptors localized in the nerve terminal regions of the mesocortical and nigrostriatal DA pathways. Microdialysis probes implanted in the striatum or the prefrontal cortex (PFC) measured dialysate DA concentrations, while the selective 5-HT2B/2C inverse agonist SB 206553 was given locally by reverse dialysis into these terminal regions.
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